5-Methyl-2-pyrrolidone → HCID 71251978, compound

HRID 2412121Notes

Reaction equation

HRID 2412121 reaction equation
C([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:33])(=O)C.[CH3:34][CH:35]1[NH:39][C:38](=[O:40])[CH2:37][CH2:36]1>>[CH3:34][CH:35]1[CH2:36][CH2:37][C:38](=[O:40])[N:39]1[C:13]1[CH:12]=[CH:11][C:10]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[C:9]([N:6]2[CH2:7][CH2:8][NH:4][C:5]2=[O:33])[CH:14]=1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 71252060HCID 71252060, compound

Product 1

HCID 71251978HCID 71251978, compoundYield 18.9%

Procedure

Using 1-acetyl-3-{5-chloro-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (182 mg) described in Preparation Example 258 and 5-methylpyrrolidin-2-one (58 mg) and by the reaction and treatment in the same manner as in Example 649, the title compound (36 mg) was obtained.

Sources & evidence

ORD record
ord-d906013c30364cf1a3767c4abbce61ca
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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