2-Pyrrolidone → HCID 71252287, compound

HRID 2412123Notes

Reaction equation

Cl[C:2]1[CH:3]=[CH:4][C:5]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[C:6]([N:8]2[CH2:12][CH2:11][N:10]([CH3:13])[C:9]2=[O:14])[CH:7]=1.[NH:32]1[CH2:36][CH2:35][CH2:34][C:33]1=[O:37]>>[CH3:13][N:10]1[CH2:11][CH2:12][N:8]([C:6]2[CH:7]=[C:2]([N:32]3[CH2:36][CH2:35][CH2:34][C:33]3=[O:37])[CH:3]=[CH:4][C:5]=2[C:15]([N:17]2[CH2:18][CH2:19][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:21][CH2:22]2)=[O:16])[C:9]1=[O:14]

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 71251926HCID 71251926, compound

Product 1

HCID 71252287HCID 71252287, compoundYield 49.1%

Procedure

Using 1-{5-chloro-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-one (55 mg) described in Preparation Example 259 and pyrrolidin-2-one (16 mg) and by the reaction and treatment in the same manner as in Example 666, the title compound (30 mg) was obtained.

Sources & evidence

ORD record: ord-4e068c8ebad740f2b4d550e603a2f8d6
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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