1,3-Propanesultam → HCID 71252923, compound

HRID 2412124Notes

Reaction equation

HRID 2412124 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[C:6]([N:8]2[CH2:12][CH2:11][N:10]([CH3:13])[C:9]2=[O:14])[CH:7]=1.[S:32]1(=[O:38])(=[O:37])[CH2:36][CH2:35][CH2:34][NH:33]1>>[O:37]=[S:32]1(=[O:38])[CH2:36][CH2:35][CH2:34][N:33]1[C:2]1[CH:3]=[CH:4][C:5]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[C:6]([N:8]2[CH2:12][CH2:11][N:10]([CH3:13])[C:9]2=[O:14])[CH:7]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71251926HCID 71251926, compound

Product 1

HCID 71252923HCID 71252923, compoundYield 41.2%

Procedure

Using 1-{5-chloro-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-one (57 mg) described in Preparation Example 259 and isothiazolidine 1,1-dioxide (24 mg) and by the reaction and treatment in the same manner as in Example 666, the title compound (28 mg) was obtained.

Sources & evidence

ORD record
ord-e7b7c8d590bf45438e1eef12678e7f2f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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