Pyridine → HCID 57064725, compound

HRID 2412312Notes

Reaction equation

HRID 2412312 reaction equation
[C:1]([OH:5])([CH3:4])([CH3:3])[CH3:2].N1C=CC=CC=1.[F:12][CH:13]([CH2:15][C:16](Cl)=[S:17])[F:14]>ClCCl>[F:12][CH:13]([CH2:15][C:16]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[S:17])[F:14]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6386tert-ButanolHCID 19880176HCID 19880176, compound

Product 1

HCID 57064725HCID 57064725, compoundYield 48.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred and ice cooled solution of t-butanol (1.2 equivalents) and pyridine (1.3 equivalents) in dichloromethane (5 parts by weight) is dropwise added difluoromethylthioacetyl chloride, and the mixture is stirred for 4 hours. The mixture is washed with water, dried and concentrated in vacuum. The residual liquid is distilled to give t-butyl difluoromethylthioacetate as an oil. Yield: 48.6%.

Workup

  1. stirringthe mixture is stirred for 4 hours
  2. washThe mixture is washed with water
  3. customdried
  4. concentrationconcentrated in vacuum
  5. distillationThe residual liquid is distilled

Sources & evidence

ORD record
ord-8739f5ea0c8943ac8c807d5c4031d379
Source dataset
uspto-grants-1985_01
Patent number
US04491547

Reaction notes

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