Dicyclohexylcarbodiimide → HCID 178451186, compound

Participants

Reaction Steps

Equimolar quantities of Z-D-Arg(NO2)-OH and H-Phe-OtBu were dissolved in DMF and coupled by adding DCC and HOBt under the conditions described in Example 1(2), DCU was filtered off, and the organic EtOAc layer of the filtrate was then extracted successively with acid, base and water, dried and crystallized from EtOAc-hexane mixture. The peptide subsequently purified with the aid of an SiO2 column has an Rf of 0.52 in To/EtOH (4:1).

Provenance & Evidence