Hydrochloric Acid → HCID 70578042, compound

Participants

Reaction Steps

A solution of 2-[2-[3-(1-piperidinylmethyl) phenoxy]ethoxy]ethanamine (0.4 g) and N-methyl-1-methylthio-2-nitro-etheneamine (0.24 g) in water (20 ml) and ethanol (20 ml) was stirred at 50° for 5h. The solution was diluted with water (20 ml) acidified to pH 1 with dilute hydrochloric acid and washed with ethyl acetate (2×50 ml). The aqueous solution was basified to pH 9 with potassium carbonate and extracted with ethyl acetate (3×50 ml). Evaporation of these organic extracts gave a yellow oil which solidified when triturated with cyclohexane. The solid was recrystallised from ethyl acetate (10 ml) to give the title compound as a white powder (0.17 g) m.p. 125.5°-126.5° .

Provenance & Evidence