Diethyl Ether → HCID 70578649, compound

HRID 2412339Notes

Reaction equation

HRID 2412339 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:18]=[CH:19][CH:20]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CS[C:23]([NH:28]C)=[CH:24][N+:25]([O-:27])=[O:26].[CH3:30]COCC>O.C(O)(C)C.C(OCC)(=O)C>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:18]=[CH:19][CH:20]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N:17]([CH3:30])[C:23]([NH2:28])=[CH:24][N+:25]([O-:27])=[O:26])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 3283Diethyl EtherHCID 1235491-Methylthio-1-methylamino-2-nitroethyleneHCID 13020536HCID 13020536, compound

Product 1

HCID 70578649HCID 70578649, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 22055037Isopropanol ethyl acetateSolvent

Procedure

A solution of 5-[3-(1-piperidinylmethyl)-phenoxy]-pentanamine (1.0 g) and 1-methylthio-1-methylamino-2-nitroethene (0.53 g) in water (20 ml) was stirred overnight at room temperature. The water was removed in vacuo and the resulting oil triturated with ethyl acetate to give a yellow solid which was dissolved in isopropanol:ethyl acetate (75:25). Addition of ether to the solution afforded the title compound (0.16 g) as a white crystalline solid, m.p. 112°-113° .

Workup

  1. customThe water was removed in vacuo
  2. customthe resulting oil triturated with ethyl acetate
  3. customto give a yellow solid which

Sources & evidence

ORD record
ord-4ee98684798249baaf7f21cd71d987e6
Source dataset
uspto-grants-1985_01
Patent number
US04491586

Reaction notes

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