Hydrochloric Acid → HCID 13132150, compound

Participants

Reaction Steps

6.2 g (0.019 mole) of 4-(2-methyl-3-chlorophenylhydrazono)-2-phenyl-oxazoline-5-one (R1 =2--CH3, R2 =3--Cl and R3 =H in the formula II) was added to 60 ml of acetone with stirring. To the resulting mixture, 3 ml of 29% solution of NH4OH (0.024 mole) was added dropwise at room temperature. Then the mixture was refluxed for 25 minutes and heating was stopped. After 3 ml of concentrated hydrochloric acid was added dropwise, and then the mixture was refluxed again for 5 minutes. The obtained reaction mixture was filtered while hot, and 80 ml of water was added to the filtrate. The obtained mixture was allowed to stand for cooling to obtain a product. The product was filtered out, washed with acetone containing water and dried. The crystal was recrystallized from 60 ml of ethanol to obtain 4.8 g of almost colorless crystal, m.p. 198°-200° C., with a yield of 78.2%.

Provenance & Evidence