Sodium Hydroxide → HCID 13135275, compound

Participants

Reaction Steps

36.2 g (0.1 mole) of N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-chlorocyclohex-1-ylsulfonamide (see Example 1) were suspended in 300 ml of methanol and 8 g (0.2 mole) of sodium hydroxide dissolved in 40 ml of water were added at room temperature. The reaction mixture was then stirred under reflux for 8 hours, evaporated in vacuo and taken up in 250 ml of water. After filtration and acidification with 2N HCl to pH 5, extraction was carried out with ethyl acetate and then the extracts were dried over sodium sulfate and evaporated. After adding n-hexane, 17.2 g (52.7% of theory) of N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-1-cyclohexenylsulfonamide were obtained, having a melting point of 163°-166° C.

Provenance & Evidence