Sodium Methoxide → HCID 20137756, compound

HRID 2412377Notes

Reaction equation

HRID 2412377 reaction equation
Cl[C:2]1[C:3]2[CH2:12][CH2:11][CH2:10][O:9][C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][C:2]1[C:3]2[CH2:12][CH2:11][CH2:10][O:9][C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 20432178HCID 20432178, compound

Product 1

HCID 20137756HCID 20137756, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6,7-Dihydro-4-hydroxy-5H-pyrano[2,3-d]pyrimidin-2-amine can be prepared from diethyl 3-chloropropylmalonate, guanidine carbonate and sodium ethoxide in ethanol. Treatment of the product ##STR56## with phosphorus oxychloride gives 4-chloro-6,7-dihydro-5H-pyrano[2,3-d]pyrimidin-2-amine and subsequent reaction with sodium methoxide in refluxing methanol affords 6,7-dihydro-4-methoxy-5H-pyrano[2,3-d]pyrimidin-2-amine.

Sources & evidence

ORD record
ord-476ae350ce6544499181813b8cb824c4
Source dataset
uspto-grants-1985_01
Patent number
US04492599

Reaction notes

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