Sodium Hydroxide → HCID 178486858, compound

Participants

Reaction Steps

A mixture of 700 mg methyl [(2-amino-ethyl)-methyl-amino]-{4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexyl}-acetate, 7 ml of methanol and 0.65 ml 4N sodium hydroxide solution is stirred for three hours at ambient temperature. Then the reaction mixture is evaporated down and extracted with ethyl acetate. The organic phase is dried on magnesium sulphate and evaporated down. The flask residue is purified by chromatography through a silica gel column with methylene chloride/methanol/conc. ammonia (98/2/0.1 auf 8/2/0.1) as eluant. The crude product is stirred with diisopropylether, suction filtered and dried.

Provenance & Evidence