2-Propanone, 1-(acetyloxy)-3-chloro- → HCID 178475908, compound

HRID 2412455Notes

Reaction equation

HRID 2412455 reaction equation
[C:1]([O:4][CH2:5][C:6](=O)[CH2:7][Cl:8])(=[O:3])[CH3:2].[C:10]([NH:13][C:14]([NH2:16])=[S:15])(=[NH:12])[NH2:11]>CC(C)=O>[OH2:3].[ClH:8].[NH:13]([C:14]1[S:15][CH:7]=[C:6]([CH2:5][O:4][C:1](=[O:3])[CH3:2])[N:16]=1)[C:10]([NH2:12])=[NH:11].[NH:13]([C:14]1[S:15][CH:7]=[C:6]([CH2:5][O:4][C:1](=[O:3])[CH3:2])[N:16]=1)[C:10]([NH2:12])=[NH:11].[ClH:8]

Participants

4

Reactant 2

HCID 384132-Propanone, 1-(acetyloxy)-3-chloro-HCID 178513045HCID 178513045, compound

Product 1

HCID 178475908HCID 178475908, compoundYield 119.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A suspension of 1-acetoxy-3-chloro-2-propanone (4.52 g) and guanylthiourea (3.55 g) in acetone (100 ml) is stirred at room temperature for 64 hours. The precipitated crystals are filtered to give 2-guanidino-4-acetoxymethylthiazole hydrochloride hemihydrate (6.2 g) as crystals melting at 170°-172° C.

Workup

  1. filtrationThe precipitated crystals are filtered

Sources & evidence

ORD record
ord-08577bd1dc4a42049dd7d286a7ef30e9
Source dataset
uspto-grants-1985_01
Patent number
US04492794

Reaction notes

Loading…