HCID 131714080, compound → HCID 178429604, compound

Participants

Reaction Steps

A mixture of t-butyl 3-methyl-7-aminoceph-3-em-4-carboxylate toluene-p-sulphonate (0.442 g.) and 2-fluoro-4-(2-trifluoroacetylaminoethyl)imidazole (0.45 g.) was stirred in acetonitrile (dried over molecular sieve, 10 ml.) at 70°-75° for 1.5 hours. The mixture was filtered and the filtrate purified on silica gel (500 g.) eluted with methylene chloride containing 1%, 2%, 3%, 4% and finally 5% v/v methanol. The relevant fractions were combined to give t-butyl 3-methyl-7-[4-(2-trifluoroacetylaminoethyl)imidazol-2-yl]aminoceph-3-em-4-carboxylate (0.34 g.) which was used without further purification.

Provenance & Evidence