Diethyl Ether → 2-Fluoro-4-methylthio-1-triphenylmethylimidazole

Participants

Reaction Steps

A mixture of 2-fluoro-1-triphenylmethylimidazole (0.328 g.) and t-butyl lithium (1.0 ml. of a 2M solution in pentane) in THF (3 ml.) was stirred at -78° for 2 hours. Dimethyl disulphide (0.18 ml.) was added and the mixture was stirred for 0.5 hours at -78° then at -15° for 1 hour. Ether was added and the organic layer washed to neutrality with water and finally with brine. The solution was dried and the solvent evaporated to give 2-fluoro-4-methylthio-1-triphenylmethylimidazole (0.368 g.), m.p. 142°-143°.

Provenance & Evidence