HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → 2-Fluoro-4-(3-phenylcarbamoyloxypropyl)-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | 2-Fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole | HCID 20432455 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Fluoro-4-(3-phenylcarbamoyloxypropyl)-1-triphenylmethylimidazole | HCID 20432451 | — |
Reaction Steps
A solution of 2-fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole in pyridine was treated with phenylisocyanate at ambient temperature. Work up as for the starting materials of Example 9 gave 2-fluoro-4-(3-phenylcarbamoyloxypropyl)-1-triphenylmethylimidazole, having the following n.m.r. spectrum in d6DMSO: 1.87 (m, 2H); 2.48 (t, 2H); 4.08 (t, 2H); 6.31 (s, 1H); 7.0-7.5 (m, 20H); 9.34 (br, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-c9bf6e9eac3a43bba6ddd1f3a7734500 |
| Source note | uspto-grants-1985_01 |