HCID 20432335, compound → 3-Isocyanatopyridine

HRID 2412488Notes

Reaction equation

HRID 2412488 reaction equation
[F:1][C:2]1[N:3]([C:14]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=[C:5]([CH2:7][CH2:8][NH:9][C:10]([NH:12][CH3:13])=[O:11])[N:6]=1>C(Cl)Cl>[N:3]1[CH:4]=[CH:5][CH:7]=[C:8]([N:9]=[C:10]=[O:11])[CH:14]=1.[F:1][C:2]1[N:3]([C:14]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=[C:5]([CH2:7][CH2:8][NH:9][C:10]([NH:12][C:13]2[CH:2]=[N:3][CH:4]=[CH:5][CH:7]=2)=[O:11])[N:6]=1

Participants

4

Reactant 1

HCID 20432335HCID 20432335, compound

Product 2

HCID 27604933-IsocyanatopyridineHCID 20432372HCID 20432372, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the same procedure as for the starting material of Example 36, except that CH2Cl2 was used as solvent, and 3-pyridylisocyanate in place of methyl isocyanate, there was obtained 1-[2-(2-fluoro-1-triphenylmethylimidazol-4-yl)ethyl]-3-(pyrid-3-yl)urea, having the following n.m.r. spectrum in d6DMSO: 2.5 (t, 2H); 3.28 (t, 2H); 6.33 (s, 1H); 7.0-7.5 (m, 16H); 7.83 (d, 1H); 8.17 (s, 1H); 8.6 (s, 1H).

Sources & evidence

ORD record
ord-c861ce954daf4c35a45810e1f7bef093
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

Loading…