HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Fluoro-4-(3-methoxypropyl)-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-Fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole | HCID 20432412 | — |
| Product | 2-Fluoro-4-(3-methoxypropyl)-1-triphenylmethylimidazole | HCID 20432336 | — |
Reaction Steps
A solution of 2-fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole in MeOH was treated with sodium metal and stirred at 65°. Work-up as for the starting material of Example 9 gave 2-fluoro-4-(3-methoxypropyl)-1-triphenylmethylimidazole, having the following n.m.r. in CDCl3 : 1.87 (m, 2H); 2.45 (t, 2H); 3.26 (s, 3H); 3.33 (t, 2H); 6.21 (s, 1H); 7.0-7.5 (m, 15H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-77916e1cebfe4908860595c79a2f4724 |
| Source note | uspto-grants-1985_01 |