HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 4-(2,3-Dihydroxypropyl)-2-fluoro-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 4-Allyl-2-fluoro-1-triphenylmethylimidazole | HCID 20432349 | — |
| Catalyst | Osmium Tetroxide | HCID 30318 | — |
| Product | 4-(2,3-Dihydroxypropyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432323 | — |
Reaction Steps
A solution of osmium tetroxide in acetone was treated with N-methylmorpholine in aqueous acetone. 4-Allyl-2-fluoro-1-triphenylmethylimidazole was added, and the mixture stirred at ambient temperature overnight. Reductive work-up with sodium metabisulphite and magnesium trisilicate, followed by extraction into ether, gave 4-(2,3-dihydroxypropyl)-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. in CDCl3 : 2.6 (d, 2H); 3.6 (m, 2H); 3.9 (m, 1H); 6.3 (s, 1H); 7.0-7.5 (m, 15H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-3c708071408c425f843efec8bd266875 |
| Source note | uspto-grants-1985_01 |