HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 4-(1-Dimethylaminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 2-Fluoro-1-trityl-1H-imidazole-4-carbaldehyde | HCID 53779028 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(1-Dimethylaminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432364 | — |
Reaction Steps
An aqueous solution of dimethylamine hydrochloride and NaCN was added to a solution of 2-fluoro-4-formyl-1-triphenylmethylimidazole in THF. After stirring 3 hours at 20°, work-up gave 4-(1-dimethylaminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole having the following n.m.r. in CDCl3 : 2.31 (s, 6H); 4.64 (s, 1H); 6.68 (s, 1H); 7.04-7.45 (m, 15H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-040ffee1a39b40b99d55380c0c2d70d4 |
| Source note | uspto-grants-1985_01 |