HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethyl-1,3-propanediamine → 4-(3-Dimethylaminopropylcarbamoyl)-2-fluoro-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| Reactant | 4-Carboxy-2-fluoro-1-triphenylmethylimidazole | HCID 20432404 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(3-Dimethylaminopropylcarbamoyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432441 | — |
Reaction Steps
2-Fluoro-1-triphenylmethylimidazole-4-carboxylic acid and 3-dimethylaminopropylamine were condensed in THF by the mixed anhydride procedure described for the preparation of starting material for Example 18, to give 4-(3-dimethylaminopropylcarbamoyl)-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. in CDCl3 : 1.8 (m, 2H); 2.3 (s, 6H); 2.4 (t, 2H); 3.5 (q, 2H); 7.0-7.6 (m, 16H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-a7828a0d66464e6da3cacdfc8727b6ff |
| Source note | uspto-grants-1985_01 |