HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-bromobutyrate → Ethyl 4-(2-fluoroimidazol-1-yl)butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | 2-Fluoro-1H-imidazole hydrochloride | HCID 12624627 | — |
| Product | Ethyl 4-(2-fluoroimidazol-1-yl)butyrate | HCID 20432450 | — |
Reaction Steps
Using the technique for the starting material of Example 74, 2-fluoroimidazole hydrochloride was alkylated with ethyl 4-bromobutyrate to give ethyl 4-(2-fluoroimidazol-1-yl)butyrate, having the following n.m.r. in CDCl3 : 1.3 (t, 3H); 1.9-2.5 (m, 4H); 3.9 (t, 2H); 4.1 (q, 2H); 6.5 (d, 1H); 6.6 (d, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-f45940424df042e48a886e1c906b8843 |
| Source note | uspto-grants-1985_01 |