Trifluoroacetic acid → HCID 131714081, compound

Participants

Reaction Steps

3-Acetoxymethyl-7-[1-(3-t-butoxycarbonylpropyl)imidazol-2-yl]aminoceph-3-em-4-carboxylic acid was treated with TFA according to the process of Example 39, except that product was isolated by trituration, to give 3-acetoxymethyl-7-[1-(3-carboxypropyl)imidazol-2-yl]amino ceph-3-em-4-carboxylic acid, having the following n.m.r. spectrum in d6DMSO+CD3CO2D: 1.6-2.4 (m, 4H); 2.0 (s, 3H); 3.5 (d, 1H); 3.7 (d, 1H); 4.0 (t, 2H); 4.7 (d, 1H); 5.0 (d, 1H); 5.2 (d, 1H); 5.6 (s, 1H); 7.1 (m, 2H).

Provenance & Evidence