HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-isothiocyanatoethane → 2-Fluoro-4-[3-(3-[2,2,2-trifluoroethyl]thioureido)propyl]-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Reactant | 4-(3-Aminopropyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432314 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Fluoro-4-[3-(3-[2,2,2-trifluoroethyl]thioureido)propyl]-1-triphenylmethylimidazole | HCID 53723255 | — |
Reaction Steps
4-(3-Aminopropyl)-2-fluoro-1-triphenylmethylimidazole was reacted in THF with 2,2,2-trifluoroethyl isothiocyanate for 2 hours. Extractive work-up and chromatography gave 2-fluoro-4-[3-(3-[2,2,2-trifluoroethyl]thioureido)propyl]-1-triphenylmethylimidazole having the following n.m.r. in CDCl3 : 1.78 (quintet, 2H); 2.43 (t, 2H); 3.5 (q, 2H); 4.25 (m, 2H); 6.24 (s, 1H); 7.0-7.35 (m, 15H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-5ad12d285b1543df9845061c4b86c362 |
| Source note | uspto-grants-1985_01 |