HCID 66717399, compound → HCID 66717323, compound

HRID 241252Notes

Reaction equation

HRID 241252 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:12](CC2C=CC(C3SC=CN=3)=CC=2)([NH2:24])[C:13]2[N:18]=[C:17]([NH:19][CH2:20][C:21]([OH:23])=[O:22])[CH:16]=[CH:15][CH:14]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Cl.N1C=CC=C(S(C(N[CH2:60][C:61]2[CH:66]=[CH:65][C:64]([C:67]3[S:68][CH:69]=[CH:70][N:71]=3)=[CH:63][CH:62]=2)C2N=C(NCC(O)=O)C=CC=2)(=O)=O)C=1>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH:12]([NH:24][CH2:60][C:61]2[CH:62]=[CH:63][C:64]([C:67]3[S:68][CH:69]=[CH:70][N:71]=3)=[CH:65][CH:66]=2)[C:13]2[N:18]=[C:17]([NH:19][CH2:20][C:21]([OH:23])=[O:22])[CH:16]=[CH:15][CH:14]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 66717399HCID 66717399, compoundHCID 66717651HCID 66717651, compound

Product 1

HCID 66717323HCID 66717323, compoundYield 95%

Procedure

Reaction and post-treatment were carried out in the same manner as in Example 2-(c) except for using (6-{(4-fluorobenzenesulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride (148 mg, 0.248 mmol) obtained in Example 4-(b) in place of (6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)-benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride to afford the title compound (122 mg) as a pale brown solid. (Yield: 95%)

Workup

  1. customReaction

Sources & evidence

ORD record
ord-ce6beaecffd94936b4029deae742f0fc
Source dataset
uspto-grants-2014_02
Patent number
US08648097B2

Reaction notes

Loading…