HRID241254

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24229487

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(C(N)(Cc2ccc(-c3nccs3)cc2)S(=O)(=O)c2cccnc2)n1

HCID86651772

未命名化合物

收率 85%

PROCEDURE

实验过程

Reaction and post-treatment were carried out in the same manner as in Example 2-(a) except for using tert-butyl(tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate (126 mg, 0.263 mmol) obtained in Reference Example 12-(d) in place of N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide, and using 4-(thiazol-2-yl)benzyl alcohol (49.7 mg, 0.260 mmol) obtained in Reference Example 4-(a) in place of text-butyl[tert-butoxycarbonyl(6-hydroxymethylpyridin-2-yl)amino]acetate to afford the title compound (145 mg) as a white foam. (Yield: 85%)

WORKUP

后处理

customReaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a579c33ede44053891cc8bc9078e3da
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08648097B2
来源说明: uspto-grants-2014_02

反应 SMILES

[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16]S(C2C=NC=CC=2)(=O)=O)[N:10]=1)([CH3:4])([CH3:3])[CH3:2].S1C=CN=C1C1C=CC(CN[S:45]([C:48]2[CH:49]=[N:50][CH:51]=[CH:52][CH:53]=2)(=[O:47])=[O:46])=CC=1.[S:56]1[CH:60]=[CH:59][N:58]=[C:57]1[C:61]1[CH:68]=[CH:67][C:64]([CH2:65]O)=[CH:63][CH:62]=1.C(OC(=O)CN(C(OC(C)(C)C)=O)C1C=CC=C(CO)N=1)CCC>>[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([C:26]([O:28][C:29]([CH3:32])([CH3:30])[CH3:31])=[O:27])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([S:45]([C:48]2[CH:49]=[N:50][CH:51]=[CH:52][CH:53]=2)(=[O:47])=[O:46])([CH2:65][C:64]2[CH:67]=[CH:68][C:61]([C:57]3[S:56][CH:60]=[CH:59][N:58]=3)=[CH:62][CH:63]=2)[NH2:16])[N:10]=1)([CH3:3])([CH3:2])[CH3:4]