Chloroform → HCID 3062231, compound

HRID 2412549Notes

Reaction equation

HRID 2412549 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[OH-].[Na+].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl.[CH:36](Cl)(Cl)[Cl:37]>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C.O>[Cl:37][C:36]1[CH:7]=[N:8][C:9]2[C:5]([C:6]=1[CH2:12][CH2:13][CH:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1)=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2

Participants

7

Reactant 4

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 12674079HCID 12674079, compound

Product 1

HCID 3062231HCID 3062231, compound

Reagents, catalysts & solvents 2

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolvent

Procedure

The operation is as in Example 1, but starting from 15 g of 4-[2-(5-methoxy-3-indolyl)-ethyl]-piperidine and 0.25 g of triethylbenzylammonium chloride in 120 ml of chloroform and 18 g of sodium hydroxide in 35 ml of water. 1.85 g of 3-chloro-6-methoxy-4-[2-(4-piperidyl)-ethyl]-quinoline are finally obtained in the form of the dihydrochloride melting at 210° C.

Sources & evidence

ORD record
ord-05c1ed88e22042dda94514cf024d17d9
Source dataset
uspto-grants-1985_01
Patent number
US04493838

Reaction notes

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