HRID241255

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID36995598

6-Chlorobenzo[b]thiophene-2-methanol

C9H7ClOS

结构：O=S(=O)(NCc1ccc(-c2nccs2)cc1)c1cccnc1

HCID66717376

未命名化合物

结构：CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(CNS(=O)(=O)c2cccnc2)n1

HCID86651773

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(C(Cc2cc3ccc(Cl)cc3s2)NS(=O)(=O)c2cccnc2)n1

HCID86651775

未命名化合物

收率 104.5%

PROCEDURE

实验过程

Reaction and post-treatment were carried out in the same manner as in Example 2-(a) except for using tert-butyl(tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate (100 mg, 0.209 mmol) obtained in Reference Example 12-(d) in place of N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide, and using (6-chlorobenzo[b]thiophen-2-yl)methanol (see WO 99/37304A, 41.5 mg, 0.209 mmol) in place of tert-butyl[tert-butoxycarbonyl(6-hydroxymethylpyridin-2-yl)amino]acetate to afford the title compound (144 mg) substantially quantitatively as a slightly yellow liquid.

WORKUP

后处理

customReaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-66a151d21a894c7d9d6c8753a5af0f98
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08648097B2
来源说明: uspto-grants-2014_02

反应 SMILES

[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[N:10]=1)([CH3:4])([CH3:3])[CH3:2].S1C=CN=C1C1C=CC(CNS(C2C=NC=CC=2)(=O)=O)=CC=1.[Cl:56][C:57]1[CH:58]=[CH:59][C:60]2[CH:64]=[C:63]([CH2:65]O)[S:62][C:61]=2[CH:67]=1>>[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([CH2:65][C:63]2[S:62][C:61]3[CH:67]=[C:57]([Cl:56])[CH:58]=[CH:59][C:60]=3[CH:64]=2)[NH:16][S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:18])=[O:19])[N:10]=1)([CH3:4])([CH3:3])[CH3:2]