Chloroform → HCID 3062243, compound

HRID 2412556Notes

Reaction equation

HRID 2412556 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]2)=[CH:2]1.[OH-].[Na+].[CH:20]([Cl:23])(Cl)Cl>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.O>[Cl:23][C:20]1[CH:2]=[N:1][C:9]2[C:4]([C:3]=1[CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]1)=[CH:5][CH:6]=[CH:7][CH:8]=2

Participants

6

Reactant 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 204318503-[2-(Piperidin-3-yl)ethyl]-1H-indole

Product 1

HCID 3062243HCID 3062243, compound

Reagents, catalysts & solvents 2

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolvent

Procedure

The operation is as in Example 1, but starting from 3.8 g of 3-[2-(3-indolyl)-ethyl]-piperidine and 0.075 g of benzyltriethylammonium chloride in 40 ml of chloroform, and 5 g of sodium hydroxide in 10 ml of water. 1.3 g of 3-chloro-4-[2-(3-piperidyl)-ethyl]-quinoline are finally obtained in the form of the dihydrated monohydrochloride melting at 75° C.

Sources & evidence

ORD record
ord-90e3ccf0a22d4a749bd1e3c2874d3bbc
Source dataset
uspto-grants-1985_01
Patent number
US04493838

Reaction notes

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