HCID 178493728, compound → HCID 178512636, compound

HRID 2412558Notes

Reaction equation

HRID 2412558 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[N:9]=1)[C:2]([NH2:4])=[NH:3].[NH:15]([C:19]1[S:20][CH:21]=[C:22]([CH2:24][CH2:25][CH2:26][CH2:27][NH:28][C:29]2[C:32](=O)[C:31](=[O:34])[C:30]=2[O:35]C)[N:23]=1)[C:16]([NH2:18])=[NH:17]>CO>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:32]2[C:31](=[O:34])[C:30](=[O:35])[C:29]=2[NH:28][CH2:27][CH2:26][CH2:25][CH2:24][C:22]2[N:23]=[C:19]([NH:15][C:16]([NH2:18])=[NH:17])[S:20][CH:21]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 178493728HCID 178493728, compoundHCID 178512644HCID 178512644, compound

Product 1

HCID 178512636HCID 178512636, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-guanidino-4-(4-aminobutyl)thiazole (0.105 g) and 1-[4-(2-guanidinothiazol-4-yl)butylamino]-2-methoxycyclobutene-3,4-dione (0.16 g) in dry methanol (5 ml) was stirred for 18 hours at room temperature. The white solid was filtered off, washed with methanol and dried in vacuo to give 1,2-bis[4-(2-guanidinothiazol-4-yl)butylamino]cyclobutene-3,4-dione, 0.16 g., m.p. 228°-229° C.

Workup

  1. filtrationThe white solid was filtered off
  2. washwashed with methanol
  3. customdried in vacuo

Sources & evidence

ORD record
ord-df7d2b29725149e2aa538ffcb7c1352e
Source dataset
uspto-grants-1985_01
Patent number
US04493840

Reaction notes

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