HCID 12800039, compound → HCID 12797250, compound

HRID 2412593Notes

Reaction equation

HRID 2412593 reaction equation
[C:1]([NH:18][C:19]1[C:20]([CH3:28])=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22]([OH:24])=[O:23])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].CC(C)([O-])C.[K+]>>[CH2:2]([C:1]1[NH:18][C:19]2[CH:27]=[CH:26][CH:25]=[C:21]([C:22]([OH:24])=[O:23])[C:20]=2[CH:28]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 12800039HCID 12800039, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 12797250HCID 12797250, compoundYield 54.2%

Procedure

A mixture of 3-(n-hexadecanamido)-2-methylbenzoic acid (6.0 g) and potassium tert-butoxide (23 g) was treated in a similar manner to that described hereinbefore in Example 1 to give 2-(n-pentadecyl)indole-4-carboxylic acid (3.1 g), in the form of a cream solid, m.p. 114°-117° C.

Workup

  1. additionwas treated in a similar manner to that

Sources & evidence

ORD record
ord-8d7c6968a3d5413d8ec8508578fc0dac
Source dataset
uspto-grants-1985_01
Patent number
US04493843

Reaction notes

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