HCID 12800025, compound → HCID 12797233, compound

HRID 2412596Notes

Reaction equation

HRID 2412596 reaction equation
[C:1]([NH:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[CH3:22])[C:16]([OH:18])=[O:17])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].CC(C)([O-])C.[K+]>>[CH2:2]([C:1]1[NH:12][C:13]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[C:15]([C:16]([OH:18])=[O:17])[CH:14]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 12800025HCID 12800025, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 12797233HCID 12797233, compoundYield 72.6%

Procedure

A mixture of 3-(n-decanamido)-4-methylbenzoic acid (6.0 g) and potassium tert-butoxide (23.5 g) was treated in a similar manner to that described hereinbefore in Example 1 to give a solid which was recrystallised from ethanol to give 2-(n-nonyl)indole-6-carboxylic acid (4.1 g), in the form of colourless crystals, m.p. 166°-169° C.

Workup

  1. additionwas treated in a similar manner to that
  2. customto give a solid which
  3. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-6eb58401586f42b5b5e3b60f977570de
Source dataset
uspto-grants-1985_01
Patent number
US04493843

Reaction notes

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