Acetic Acid → HCID 12799966, compound

Participants

Reaction Conditions

Reaction Steps

(RS)-2-(n-undecyl)indoline-5-carboxylic acid hydrochloride (32.9 g) in ethanol (150 ml) containing sodium hydroxide (10 g) and water (38 ml) was stirred and refluxed for 1.5 hours. Glacial acetic acid (15 ml) was added to the hot solution and the mixture was cooled to 0° C. and then diluted with water (600 ml). The solid was collected and was recrystallized from methanol to give (RS)-2-(n-undecyl)indoline-5-carboxylic acid (25.7 g), in the form of a white solid, m.p. 99°-103° C.

Provenance & Evidence