Methyl iodide → HCID 12800001, compound

Participants

Reaction Steps

A mixture of (RS)-2-(n-undecyl)indoline-5-carboxylic acid hydrochloride (6.8 g), sodium hydroxide (6.8 g), water (25 ml), ethanol (75 ml) and methyl iodide (10 ml) was heated under reflux for 1 hour. Methyl iodide (5 ml) was added and the mixture was heated for 30 minutes, then poured into water and acidified with acetic acid. The product was collected and recrystallised from methanol to give (RS)-1-methyl-2-(n-undecyl)indoline-5-carboxylic acid (3.0 g), in the form of white needles, m.p. 102°-104° C.

Provenance & Evidence