Ethanol → HCID 53743878, compound

HRID 2412654Notes

Reaction equation

HRID 2412654 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1C=O.[NH2:8][CH2:9][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13].C(O)C>O>[S:1]1[CH:5]=[CH:4][CH2:3][C:2]1=[N:8][CH2:9][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]

Participants

5

Reactant 3

HCID 702EthanolHCID 73642-ThiophenecarboxaldehydeHCID 1596920Diethyl (aminomethyl)phosphonate

Product 1

HCID 53743878HCID 53743878, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

11.2 g. (0.1 mol) Thien-2-aldehyde are added to 16.7 g. (0.1 mol) diethyl aminomethylphosphonate in 200 ml. absolute ethanol and the mixture is heated under reflux for 30 minutes. The water formed during the reaction is removed by azeotropic distillation. After complete evaporation of the solvent, 28 g. (about 100%) of a yellow oil are collected, which is pure according to LC, TLC and GC.

Workup

  1. temperatureunder reflux for 30 minutes
  2. customis removed by azeotropic distillation
  3. customAfter complete evaporation of the solvent, 28 g
  4. custom(about 100%) of a yellow oil are collected

Sources & evidence

ORD record
ord-e2e1c1e0f7d840978004712ce53818d5
Source dataset
uspto-grants-1985_01
Patent number
US04493931

Reaction notes

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