Diethyl Ether → HCID 101928054, compound

Participants

Reaction Steps

A sample of didemnin B (1.0 mg) was dissolved in 1 ml of pyridine and 0.5 ml of acetic anhydride was added. The solution was stirred at room temperature for 18 hours and evaporated to dryness. The residue obtained was dissolved in 3 ml of ether and extracted with water (4×1.5 ml). Evaporation of the dried (Na2SO4) organic phase afforded 0.90 mg (84% yield) of diacetyldidemnin B as a white, amorphous solid, mp 128°-131° C.; Rf 0.65; HPLC retention time (84:16 methanol:water) 9.1 min; EIMS (70 eV) major ions at m/z 70 (100% of base peak), 86 (12), 100 (13), 121 (45), 154 (18), 184 (15), 212 (20), 224 (4), 268 (9), 339 (9), 422 (3); HREIMS gave a molecular ion at m/z 1195.6604 which corresponds to the expected molecular formula C61H93N7O17 (Δ=-2.2 mmu).

Provenance & Evidence