Acetic Anhydride → HCID 6793490, compound

HRID 2412771Notes

Reaction equation

HRID 2412771 reaction equation
[OH:1][N:2]=[C:3]([C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:15](OC(=O)C)(=[O:17])C>C(O)=O>[OH:1][N:2]=[C:3]([C:9]1[N:10]=[C:11]([NH:14][CH:15]=[O:17])[S:12][CH:13]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 6738988Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate

Product 1

HCID 6793490HCID 6793490, compoundYield 76.7%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Ethyl 2-hydroxyimino-2-(2-aminothiazol-4-yl)acetate (syn isomer) (126.4 g.), formic acid (81.3 g.) and acetic anhydride (180 g.) were treated in a similar manner to that of Preparation 20 (5) to give ethyl 2-hydroxyimino-2-(2-formamidothiazol-4-yl)acetate (syn isomer) (109.6 g.).

Sources & evidence

ORD record
ord-20af5300c82547cea20cf625cceef363
Source dataset
uspto-grants-1985_01
Patent number
US04493833

Reaction notes

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