Pyridine-3-sulfonyl chloride → N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide

HRID 241282Notes

Reaction equation

HRID 241282 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7](Cl)(=[O:9])=[O:8])[CH:2]=1.Cl.[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19][CH:18]=1.Cl.C1(C2N=NC(CN)=CC=2)C=CC=CC=1>>[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[C:17]1[CH:18]=[CH:19][C:20]([CH2:21][NH:22][S:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)(=[O:9])=[O:8])=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 3164136Pyridine-3-sulfonyl chlorideHCID 51138530(4-(Thiazol-2-yl)phenyl)methanamine hydrochlorideHCID 66717660(6-Phenylpyridazin-3-ylmethyl)amine hydrochloride

Product 1

HCID 66717376N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamideYield 80%

Procedure

Reaction and post-treatment were carried out in the same manner as in Reference Example 2-(d) except for using 3-pyridylsulfonyl chloride (495 mg, 2.79 mmol), and using 4-(thiazol-2-yl)benzylamine hydrochloride (687 mg, 2.61 mmol) obtained in Reference Example 4-(d) in place of (6-phenylpyridazin-3-ylmethyl)amine hydrochloride to afford the title compound (689 mg) as a white solid. (Yield: 80%)

Workup

  1. customReaction

Sources & evidence

ORD record
ord-961dbb2621c54b57af6ca6936a4b6441
Source dataset
uspto-grants-2014_02
Patent number
US08648097B2

Reaction notes

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