Methyl iodide → HCID 13370480, compound

Participants

Reaction Steps

To 30 mmol. of the product of Example 6 in 300 ml. of ethanol is added 33 ml. of 1 N sodium hydroxide followed by the slow addition of 54 mmol. of methyl iodide. After two hours the reaction mixture is evaporated to one fourth its volume, 100 ml. of water is added and the product is obtained by extraction into methylene chloride. The methylene chloride is removed by evaporation and the product is recrystallized from ethyl acetatehexane to afford an 89% yield (m.p. 105°-108° C.) of the title compound.

Provenance & Evidence