Sodium Hydroxide → 6-(11-Hydroxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol

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Reaction Steps

Sodium hydroxide (7 g) is added to a solution of 6-(11-acetoxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol (34 g) in methanol (300 ml) and the mixture is stirred at room temperature for 2 hours. To the reaction mixture is neutralized with 5N--HCl and the solvent is distilled off, whereupon crude crystals are obtained. These crystals are rinsed with water and recrystallized from ether-hexane (1:1). The above procedure yields colorless needles of 6-(11-hydroxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol (30 g), m.p. 81° C.

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