Phosphorus tribromide → HCID 21275134, compound

Participants

Reaction Steps

21.6 g (0.07 mole) of 1-(p-tert.-butyl-phenyl)-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-1-propanol (obtained according to Example 2) were dissolved in 250 ml of petroleum ether with 1.9 ml of pyridine and a solution of 2.9 ml (0.03 mole) of phosphorus tribromide in 50 ml of petroleum ether was added dropwise at -5° to -10° C. The mixture was subsequently stirred at room temperature for 3 hours and the precipitate was filtered off, washed with petroleum ether and dissolved in chloroform. The chloroform phase was washed with sodium bicarbonated solution, dried over sodium sulphate and concentrated in vacuo. 23 g (88% of theory) of 1-bromo-1-(p-tert.-butyl-phenyl)-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-propane were obtained as a viscous oil.

Provenance & Evidence