3,4-Dichlorophenyl isocyanate → HCID 20431222, compound

Participants

Reaction Steps

6.8 g (0.021 mole) of 1-(p-tert.-butyl-phenyl)-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-1-propanol (obtained according to Example 2) and 0.6 mole of triethylamine were dissolved in 60 ml of acetonitrile, and a solution of 4.0 g of 3,4-dichlorophenyl isocyanate in 10 ml of acetonitrile was added dropwise at room temperature. The mixture was subsequently stirred under reflux for one hour, cooled and concentrated. The residue was taken up in ethyl acetate and the ethyl acetate was washed with water, dried over sodium sulphate and concentrated. 8.2 g (70% of theory) of 1-(p-tert.-butyl-phenyl)-1-(3,4-dichlorophenyl-carbamoyloxy)-2-methyl-3-(2,6-dimethylmorpholin-4-yl)-propane were obtained as a viscous oil.

Provenance & Evidence