Potassium Carbonate → HCID 54133619, compound

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Reaction Steps

2-Amino-6-chloropurine (0.509 g, 3.00 mmole), 4-bromo-2-hydroxybutyric acid ethyl ester (0.633 g, 3.00 mmole; prepared according to Example 1) and anhydrous potassium carbonate (0.415 g, 3.00 mmole) were mixed with 10 g of dimethyl formamide and the mixture stirred at room temperature during 65 hours. The mixture was then filtered and the filtrate evaporated at a pressure of 0.1 mm Hg. The crystalline residue was triturated with 8 ml of chloroform and the undissolved material filtered off and washed with 2 ml of chloroform. The material obtained was then triturated with 5 ml of water and the undissolved material filtered off and washed with 2 ml of water. Recrystallization from 11 ml of ethanol gave 0.360 g product. M.P. 163°-4° C. (uncorr.) UV spectra(ethanol): λmax (nm) 311, 248. Analyses--Found: C 43.90; H 4.78; Cl 11.72; N 23.52; O 15.90%. Calculated for C11H14ClN5O3 : C 44.08; H 4.71; Cl 11.83; N 23.37; O 16.01%.

Provenance & Evidence