Potassium Carbonate → HCID 54393076, compound

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Reaction Steps

4-Bromo-2-fluorobutyric acid ethyl ester (0.23 g), 2-amino-6-chloropurine (0.19 g) and anhydrous potassium carbonate (0.15 g) were mixed and stirred in dimethylformamide (3.7 ml) at room temperature for two days. The solution was filtered and evaporated in vacuo. The residue was triturated with chloroform (4+2 ml) and the clear chloroform solution was evaporated to give the desired product (0.24 g, 72%). TLC (silica gel, i-propanol-water-conc. ammonia 8-1-1): Rf =0.76. NMR (CDCl3, Me4Si)δ: 1.26 (t, CH3); 2.4-2.5 (m, CH2); 4.2-4.3 (t and q, NCH2 and CO2CH2); 4.77 and 5.03 (CHF, J=51 Hz); 5.2 (NH2); 7.77 (8-CH).

Provenance & Evidence