Pyridine → HCID 73192844, compound

To a solution of 2-benzofuran carbaldehyde (1.00 g, 6.85 mmol) in methanol (20 ml) were added hydroxylammonium chloride (530 mg, 7.63 mmol) and pyridine (2.8 ml), followed by stirring at room temperature for 6.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure. Ethyl acetate was added to the resulting residue, followed by washing sequentially with a 5% aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogen carbonate solution and then a saturated aqueous sodium chloride solution. The resulting organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to afford the title compound (1.07 g) as a white solid. (Yield: 97%)

1. customAfter completion of the reaction
2. concentrationthe reaction solution was concentrated under reduced pressure
3. additionEthyl acetate was added to the resulting residue
4. washby washing sequentially with a 5% aqueous potassium hydrogensulfate solution
5. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure

ORD record

ord-e55453a128ba431bbbda205fa77ee810

Source dataset

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08648097B2