Pyridine-3-sulfonyl chloride → N-(Benzofuran-2-ylmethyl)pyridin-3-ylsulfonamide

HRID 241289Notes

Reaction equation

HRID 241289 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7](Cl)(=[O:9])=[O:8])[CH:2]=1.[O:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[CH:13]=[C:12]1[CH2:20][NH2:21].Cl.C1(C2N=NC(CN)=CC=2)C=CC=CC=1>>[O:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[CH:13]=[C:12]1[CH2:20][NH:21][S:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)(=[O:9])=[O:8]

Participants

4

Reactant 3

HCID 3164136Pyridine-3-sulfonyl chlorideHCID 190793482-(Aminomethyl)benzofuranHCID 66717660(6-Phenylpyridazin-3-ylmethyl)amine hydrochloride

Product 1

HCID 66717414N-(Benzofuran-2-ylmethyl)pyridin-3-ylsulfonamideYield 96%

Procedure

Reaction and post-treatment were carried out in the same manner as in Reference Example 2-(d) except for using 3-pyridylsulfonyl chloride (154 mg, 0.867 mmol), and using (benzofuran-2-ylmethyl)amine (128 mg, 0.870 mmol) obtained in Reference Example 10-(b) in place of (6-phenylpyridazin-3-ylmethyl)amine hydrochloride to afford the title compound (239 mg) as a white solid. (Yield: 96%)

Workup

  1. customReaction

Sources & evidence

ORD record
ord-db99af8c26844de9b5d3b8ca23c8049d
Source dataset
uspto-grants-2014_02
Patent number
US08648097B2

Reaction notes

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