Ammonia → HCID 70448823, compound

Participants

Reaction Steps

7-(2,3-Epoxypropoxy)flavone (13.3 g, 0.045 mol) in a presurre bottle was treated with a methanolic solution (90 ml) containing 1.87 g of ammonia (0.11 mol). The bottle was sealed and the suspension was heated at 50° for 12 hrs. A tlc (15% MeOH/CHCl3) indicated that the starting material was gone, and the reaction mixture was cooled and filtered. The solid (5.32 g) thus obtained was shown by tlc to be a byproduct, m.p. 209°-12°. The filtrate, upon evaporation, afforded 7.0 g of a yellow solid, m.p. 121°-27°, which was purified by high pressure liquid chromatography to give 1.85 g of yellow powder, m.p. 154°-56°. (13% yield). The hydrochloride salt was prepared and recrystallized from MeOH, m.p. 191°-2°.

Provenance & Evidence