4-(1,3-Thiazol-2-yl)benzaldehyde → (4-(Thiazol-4-yl)phenyl)methanol

HRID 241296Notes

Reaction equation

HRID 241296 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=2)[N:3]=[CH:2]1.S1C=CN=C1C1C=CC(C=O)=CC=1>>[S:1]1[CH:5]=[C:4]([C:6]2[CH:7]=[CH:8][C:9]([CH2:10][OH:11])=[CH:12][CH:13]=2)[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 105356554-(1,3-Thiazol-2-yl)benzaldehydeHCID 150453304-(Thiazol-4-yl)benzaldehyde

Product 1

HCID 66717421(4-(Thiazol-4-yl)phenyl)methanolYield 83%

Procedure

Reaction and post-treatment were carried out in the same manner as in Reference Example 4-(a) except for using 4-(thiazol-4-yl)benzaldehyde (1.28 g, 6.76 mmol) obtained in Reference Example 15-(a) in place of 4-(thiazol-2-yl)benzaldehyde to afford the title compound (1.07 g) as a white solid. (Yield: 83%)

Workup

  1. customReaction

Sources & evidence

ORD record
ord-93107596b21b4af3809dd8fb75a5d599
Source dataset
uspto-grants-2014_02
Patent number
US08648097B2

Reaction notes

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