HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyrimidine → [4-(Pyrimidin-2-yl)phenyl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyrimidine | HCID 78345 | — |
| Reactant | 4-(Hydroxymethyl)benzeneboronic acid | HCID 2734706 | — |
| Product | [4-(Pyrimidin-2-yl)phenyl]methanol | HCID 15597455 | 100.6% |
Reaction Steps
Reaction and post-treatment were carried out in the same manner as in Reference Example 13 except for using 4-hydroxymethylphenylboronic acid (144 mg, 0.948 mmol), and using 2-bromopyrimidine (101 mg, 0.635 mmol) in place of 4-bromopyridazine to afford the title compound (119 mg) substantially quantitatively as a slightly yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648097B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-3086f95932f24efdba1057ec9d959eba |
| Source note | uspto-grants-2014_02 |