Hydroxyamine hydrochloride → HCID 86125164, compound

Participants

Reaction Steps

A solution of 188.6 g. of 3,4-bis(4-methoxyphenyl)-2-cyclohexen-1-one and 84.8 g. of hydroxylamine hydrochloride in 1.5 liters of methanol was heated to reflux for three hours. The reaction was then stirred overnight at room temperature and evaporated in vacuo. To the residue were added one liter of ethyl acetate and 600 ml. of water. The layers were separated and the organic layer was washed three times each with 500 ml. of water. The organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to provide 192.59 g. of the title oxime intermediate.

Provenance & Evidence