Sodium Hydroxide → HCID 13370669, compound

Participants

Reaction Steps

A solution of 10.0 g. of 4'-acetamido-4,4"-dimethoxy-1,1':2',1"-terphenyl in 250 ml. of 2B ethanol and 30 ml. of 5N sodium hydroxide was allowed to reflux overnight. Another 30 ml. of 5N sodium hydroxide were added and the reaction was allowed to reflux an additional 24 hours. The solution was then treated with 23 ml. of hydrochloric acid and evaporated in vacuo. The residue was taken up in 500 ml. of diethyl ether and 500 ml. of ethyl acetate. The organic solution was washed with water until neutral, dried over sodium sulfate, filtered, and evaporated in vacuo. The residue was crystallized from diethyl ether to provide 6.42 g. of the desired amino intermediate, m.p. about 115°-117° C.

Provenance & Evidence